MAF – The Ultimate Breakthrogh In Antiaging and Longevity.
GcMAF (Gc Macrophage Activating Factor) is available in different forms, improving over time for better safety and effectiveness. All our products are developed by Saisei and hold patents globally.
Dietary MAF not only activates macrophages but also supports cellular rejuvenation. Studies in mice have shown telomere elongation, increased telomerase (TERT and TERC) expression, and enhanced Klotho gene activity, promoting a more youthful state.
Anti-aging and longevity
Experience the groundbreaking innovation in anti-aging science with Dietary MAF—the only clinically proven solution to extend telomeres by an extraordinary 23% within just six months. Carefully developed by Saisei Pharma, these products are designed not only to enhance your health and appearance but to help you achieve the remarkable goals of looking 20 years younger and living vibrantly well past a century.
Aging is a natural part of life, yet our understanding of it has advanced significantly. Today, there are effective ways to slow this process. Central to these developments are macrophages, vital cells that play a key role in strengthening the immune system and eliminating damaged or unhealthy cells. These remarkable cells contribute to essential functions such as tissue repair, rejuvenation, and regeneration. They also provide robust protection against infections and unchecked tumor growth.
Dietary MAF harnesses cutting-edge science to challenge the inevitability of aging, fostering a life filled with vitality and resilience. Its efficacy is underscored by detailed analyses, including studies on the impact of MAF capsules on telomere length, which have demonstrated remarkable outcomes.
Analysis of the effect of taking MAF capsules on telomere length changes
Aging has long been considered inevitable—but scientific advances now suggest it can be slowed, halted, or even reversed. MAF Triple, a next-generation Macrophage Activating Factor (MAF) supplement, plays a crucial role in immune optimization, cellular rejuvenation, and longevity support.
New research into DNA methylation, telomeres, and epigenetic aging clocks is redefining our understanding of aging. These insights confirm that biological age matters more than chronological age, and with the right interventions—such as MAF Triple —we can actively extend healthspan and reverse cellular aging.
Unlocking the Secrets of Telomeres & Aging
Ever wondered why we age? The answer lies in telomeres —the protective caps at the ends of our chromosomes.
Degalactosylated Whey Protein (D-WP) Study – Effects on Telomere Length in Mice
A separate experimental study examined the effects of D-WP on telomere length and telomerase gene expression in young and aged mice.
📌 Findings:
✔ D-WP increased telomere length by 154% in young mice, while regular whey protein (WP) showed only a 121% increase.
✔ D-WP significantly upregulated telomerase reverse transcriptase (TERT) and telomerase RNA component (TERC) gene expression in peripheral blood.
✔ In aged mice, D-WP restored telomere length to youthful levels.
📌 Implication: D-WP, a key component in MAF Triple, enhances telomere maintenance, supporting longevity and cellular health.
🔗 Access the full study: Scientific Reports (2024)
Phase 2 Clinical Trial in Japan
📌 Study Objective: Evaluating the efficacy of Dietary MAF for rejuvenation and longevity
📌Number of Participants: 161
📌Results: ✔ Telomere length increased by 12% at 3 months
✔ Telomere length increased by 23% at 6 months
✔ Biological age reduction observed within 6 months of MAF Triple intake
🔬 Ongoing Research: A similar clinical trial is currently being conducted in Indonesia to further evaluate MAF Triple’s rejuvenation and longevity effects.
Can Telomere Elongation Slow Aging?
Our latest research shows that MAF Triple has demonstrated telomere elongation in mice. Telomeres, the protective caps at the ends of chromosomes, shorten with each cell division, leading to aging and age-related diseases.
The Science of Aging – How Does It Work?
Aging isn’t just about time—it’s a biological process driven by molecular changes, particularly:
📌 Telomere Shortening – Limits cell division, leading to tissue degeneration and organ decline.
📌DNA Methylation Alterations – Epigenetic changes that influence gene activity, driving aging and disease.
📌Oxidative Stress & Chronic Inflammation – Accelerate cellular damage and tissue aging.
Why Are Telomeres Important?
- They protect our genetic code from damage.
- They prevent cell malfunction and errors in DNA replication.
- Their length determines how well our cells function over time.
What Happens When Telomeres Shorten?
- Cells stop dividing, leading to aging and tissue degeneration.
- Increased risk of diseases like heart disease, cancer, and immune decline.
Association with Aging
Telomere Shortening Over Time:
Each time a cell divides, a small portion of telomeric DNA is lost. Over time, telomeres become too short to protect the chromosome, leading to genomic instability.
Cellular Senescence and Aging:
Critically short telomeres signal cells to stop dividing, entering a state called senescence. This contributes to aging by reducing the body’s ability to regenerate tissues.
Association with Aging
Link to Age-Related Diseases:
Shortened telomeres have been associated with age-related conditions such as cardiovascular diseases, neurodegenerative disorders, and weakened immune function.
Role of Telomerase:
Some cells, like stem cells and cancer cells, activate an enzyme called telomerase, which extends telomeres and allows continued division. In normal somatic cells, telomerase activity is low, leading to gradual telomere shortening.
What’s the Difference Between Young and Old in DNA Methylation?
DNA methylation is a critical epigenetic marker that determines how genes are expressed over time.
🧬 Key Differences:
- Young DNA: Balanced methylation patterns, maintaining healthy gene expression.
- Aged DNA:
- ✔ Global Hypomethylation – Leads to genomic instability & weakened cell function.
- ✔ Local HyperMethylation in CpG Islands – Causes inappropriate gene silencing, impairing regeneration.
Why This Matters?
Research on telomere maintenance, including dietary interventions like Degalactosylated Whey Protein (D-WP), MAF Capsules Triple, is being explored for its potential role in extending healthy lifespan and delaying age-related decline.
How Does MAF Triple Help?
MAF Triple may help restore optimal methylation balance, supporting youthful gene expression and cellular repair.
Biological Aging Clocks – How Old Are You, Really?
🕰 Chronological age ≠ Biological age
Your birth year doesn’t define your health, but your biological markers do.
📌 Key Aging Biomarkers (Aging “Clocks”):
1️⃣ Telomere Length – Directly correlates with cell longevity.
2️⃣ DNA Methylation Clocks – Predict lifespan & biological health.
Studies suggest DNA methylation may be the most accurate aging clock.
✅It can estimate biological age & predict longevity
✅It helps identify anti-aging compounds—like MAF Triple
📌 Example:
A study on DNA methylation found it predicts all-cause mortality in later life better than telomere length alone.
Can We Reverse Aging? The Answer is YES!
Cutting-edge research suggests that aging isn’t fixed—it’s reversible.
📌 What if we could:
- Restore telomere length?
- Reprogram DNA methylation to youthful patterns?
- Reduce oxidative stress & inflammation?
MAF Triple may be a key player in making this possible.
Clues from Nature – Why Do Some Animals Live
Over 200 Years?
Certain species, like bats, live over 10x longer than expected for their body size.
✅They resist aging & disease naturally.
✅Their epigenetic patterns stay youthful.
📌 If humans could replicate this biology, we could live up to 240 years looking young!
Could Immune Proteins Have Anti-Ageing Benefits?
Researchers in Japan are investigating whether an IMMUNE-BOOSTING PROTEIN MIGHT HAVE USES IN SLOWING AGE-RELATED DECLINE and improving cognition as societies around the world are rapidly ageing
Key Selling Points of MAF
MAF Series is approved as “Health Food” in Japan and in some European countries.
Saisei Pharma’s immune activating food products are safe and made exclusively from natural ingredients.
MAF = Macrophage Activating Factor Dietary MAF boosts your immunity by activating the immune cells without any side effects and help you stay young and healthy.
MAF Capsules Triple is our new and improved version of MAF Capsules; it contains 3 times the active ingredient!!
A human clinical trial showed a 23% increase in telomere length within 6 months, supporting cellular longevity.
Increases expression of telomerase (TERT & TERC), essential for telomere repair and cellular rejuvenation.
Boosts the Klotho gene, which plays a key role in longevity and protects against age-related diseases.
Helps reduce signs of aging, including cognitive decline, muscle loss, and cardiovascular issues.
Studies in mice and ongoing human trials in Japan and Indonesia highlight MAF’s ability to promote a healthier, longer life.
Telomere preservation and Klotho activation are linked to a lower risk of diabetes, osteoarthritis, cardiovascular disease, and more.
A study on elderly dementia patients in Japan is assessing MAF’s real-world impact on brain health.
Clinical studies confirm measurable improvements in biological aging markers, reinforcing MAF’s effectiveness.
Developed by leading researchers, including Inui’s team, at the forefront of longevity and cellular health research.