The Klotho Gene and MAF – Unlocking the Key to Healthy Aging

What is the Klotho Gene – and How Can We Activate It?

The Klotho gene is often called the “longevity gene.” It produces a protein that acts like an anti-aging hormone. This protein supports brain health, metabolism, and organ function.
However, as we age, Klotho levels naturally decrease—especially after the age of 40.
As a result, the risk of cognitive decline, heart disease, and kidney problems rises.
Discover how it works—and how MAF may help support it naturally.

Why Does Klotho Matter?

In studies, mice with no Klotho lived 80% shorter lives.
In contrast, mice with increased Klotho levels lived 30% longer than normal.
Therefore, Klotho may play a key role in how we age.

📌Klotho deficiency shortens lifespan by 80% (mouse studies)

📌Klotho overexpression increases lifespan by 30%

📌α-Klotho is an anti-aging hormone found in kidneys, brain, blood, and muscles

📌Soluble α-Klotho levels decrease after age 40

Klotho & Brain Function

Klotho doesn’t just affect lifespan.
It also helps maintain memory, learning, and cognitive performance.
For example, in rhesus monkeys, higher Klotho levels improved memory—even in old age.
Moreover, Klotho protects the brain from inflammation and damage.

📌50% of mammals experience cognitive decline with age

📌Klotho enhances memory, synaptic plasticity, and cognition

📌Expression of Klotho drops in aged monkey brains

Klotho and Age-Related Diseases

Low Klotho Levels Linked to Age-Related Diseases

📌Associated with cardiovascular disease, diabetes, sarcopenia, cognitive decline, kidney disease, and more

📌Decreasing Klotho accelerates aging-related disease onset

Can We Boost Klotho?

Recent studies suggest MAF  may help.
In fact, when mice were given Dietary MAF, their Klotho levels increased significantly in the:

■Plasma

■Kidneys

■Brain (including hypothalamus and amygdala)

Compared to whey protein, MAF was more effective at raising Klotho levels

📌Klotho naturally declines with age, but may be supported through nutrition

📌MAF shows promise as a natural supplement to enhance α-Klotho levels

📌Targeting Klotho may support immunity, cognition, and lifespan

Boosting Klotho
with MAF Triple

Protecting Klotho May Be Key to Healthy Longevity

A groundbreaking experiment showed that dietary MAF significantly increased α-Klotho levels in mice.

✅ Plasma α-Klotho levels: Nearly doubled compared to water and whey protein groups.

✅ Brain (Hypothalamus & Amygdala): Markedly increased α-Klotho content.

✅ Kidney: Strongest α-Klotho increase—vital since kidneys produce ~80% of circulating α-Klotho.

8-day test | 60 μg/ml whey protein in water | Measured via ELISA

This research highlights MAF’s powerful potential in supporting anti-aging and longevity.

Association with Aging

Link to Age-Related Diseases:

Shortened telomeres have been associated with age-related conditions such as cardiovascular diseases, neurodegenerative disorders, and weakened immune function.

Role of Telomerase:

Some cells, like stem cells and cancer cells, activate an enzyme called telomerase, which extends telomeres and allows continued division. In normal somatic cells, telomerase activity is low, leading to gradual telomere shortening.

Could Immune Proteins Have Anti-Ageing Benefits?

Researchers in Japan are investigating whether an IMMUNE-BOOSTING PROTEIN MIGHT HAVE USES IN SLOWING AGE-RELATED DECLINE and improving cognition as societies around the world are rapidly ageing

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